We use genomic and other laboratory-based methods to define the causes of pediatric musculoskeletal disorders and to design better treatments. Major areas of investigation include:

• Developmental Mechanisms of Idiopathic Scoliosis: This program, funded by NICHD P01HD084387, is a collaboration with Dr. Lila Solnica-Krezel, Washington University in St. Louis, and Dr. Nadav Ahituv, University of California, San Francisco.
• G.O.O.D. (Genomics of Orthopaedic Disorders) for Kids Program: This program uses state-of-the-art methods to understand targeted rare musculoskeletal disorders at the molecular level.
• Translating Genomics into Early Onset Scoliosis Clinical Care: This program supports whole exome sequencing 100 children with early onset “infantile” idiopathic scoliosis and their parents to discover